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Prim Health Care Res Dev. 2014 Apr;15(2):134-42. doi: 10.1017/S1463423613000121. Epub 2013 Apr 25

Beasant L, Mills N, Crawley E

In conclusion it was found that adolescents and their mothers value receiving a diagnosis from a specialist service and making progress in managing CFS/ME. General practitioners should support adolescents with CFS/ME in accessing CFS/ME specialist services, consistent with current guidance.

Eur Child Adolesc Psychiatry. 2009 Nov;18(11):683-9. doi: 10.1007/s00787-009-0029-4. Epub 2009 May 19

Crawley E, Hunt L, Stallard P.

Anxiety symptoms are commonly described in children with chronic fatigue syndrome or myalgic encephalopathy (CFS/ME). This study looked at the prevalence and type of anxiety symptoms in children with CFS/ME compared with a normal European population.Separation anxiety and social phobia were the most clearly elevated in paediatric CFS/ME.

This study evaluated the presence of CFS and FM in patients primarily affected by MCS. In conclusion 96% of the patients studied share the case definition criteria of Chronic Fatigue Syndrome and one fourth of them also that of Fibromyalgia.

Sarah Myhill, Norman E. Booth,John McLaren Howard

QJM. 2014 Mar 13.

Chen CS, Lin WM, Yang TY, Chen HJ, Kuo CN, Kao CH

This study shows that the incidence rate of fracture was higher in the CFS cohort than in the non-CFS cohort although the mechanism for developing CFS-related fracture remains unclear.

NICE Clinical Guidelines, No. 53

London: Royal College of General Practitioners (UK); August 2007

The guideline covers care provided by healthcare professionals who have direct contact with and make decisions about the care of people with chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy) (CFS/ME). It covers care provided in primary and secondary care, and in specialist centres/teams in the UK.

This is the full version which includes reference to chemical, electrical and food sensitivities as symptoms of ME/CFS. The relevant section is part of Chapter 7 ‘People with severe CFS/ME’, search for “7.4.1”. For more information click here.

Åsa Sullivan, Carl E Nord and Birgitta Evengård

Disturbances in intestinal microbial ecology and in the immune system of the host have been implicated as a part of the pathogenesis(cause of the disease) in chronic fatigue syndrome. This study evaluates the effects of probiotics on fatigue and physical activity in CFS patients.

Can Fam Physician. 2010 Feb;56(2):e57-65.

Lavergne MR, Cole DC, Kerr K, Marshall LM

The aim of this study was to characterize patients diagnosed with multiple chemical sensitivity (MCS), chronic fatigue syndrome (CFS), or fibromyalgia (FM), to compare their level of function with Canadian population average values, and to assess factors associated with function.

J Transl Med. 2014 Apr 23;12(1):104. doi: 10.1186/1479-5876-12-104.

Keller BA, Pryor JL, Giloteaux L.

This study confirms that repeated cardiopulmonary exercise tests (CPETs) warrant consideration as a clinical indicator for diagnosing ME/CFS. If based on only one CPET test classification could be misidentified.

Arch Dis Child. 2009 Oct;94(10):757-62. doi: 10.1136/adc.2008.143032. Epub2008 Nov 11.

Haig-Ferguson A, Tucker P, Eaton N, Hunt L, Crawley E.

This study concluded that children with CFS/ME appear to experience problems with attention, which may have adverse implications for verbal memory. These cognitive problems may explain some of the educational difficulties associated with CFS.

New Microbiol. 2014 Jan;37(1):17-24. Epub 2014 Jan 15.

Rasa S, Nora-Krukle Z, Chapenko S, Krumina A, Roga S, Murovska M.

Xenotropic murine leukemia virus-related virus (XMRV) has been considered a possible trigger of myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS).The aim of this study was to analyse the frequency of XMRV proviral sequences in peripheral blood leukocyte (PBL) DNA from 150 patients with ME/CFS and 30 apparently healthy individuals.

Child Care Health Dev. 2012 Jul;38(4):505-12. Epub 2011 Sep 1.

Missen A, Hollingworth W, Eaton N, Crawley E.

Paediatric chronic fatigue syndrome or myalgic encephalopathy (CFS/ME) is relatively common and children can be severely affected attending little or no school for extended periods. This study looks at the financial impact of having a child with CFS/ME and the impact on parental mood.

Psychoneuroendocrinology. 2014 Apr;42:199-206. doi: 10.1016/j.psyneuen.2014.01.017. Epub 2014 Jan 30

Nijhof SL, Rutten JM, Uiterwaal CS, Bleijenberg G, Kimpen JL, Putte EM

There is accumulating evidence of hypothalamic-pituitary-adrenal axis(HPA)(these are endocrine glands that produce hormones in the body) hypofunction(decreased function)in chronic fatigue syndrome (CFS). The objective of this study was to assess the role of the HPA-axis in adolescent CFS and recovery from adolescent CFS.

Oxid Med Cell Longev. 2013;2013:831969. doi: 10.1155/2013/831969. Epub 2013 Jul 7

Caccamo D, Cesareo E, Mariani S, Raskovic D, Ientile R, Currò M, Korkina L, De Luca C.

This study looks at various genetic variants to see whether they represent a genetic risk factor for sensitivity related illnesses(SRI).